山梨大学应用化学系
佐藤实验室

2024

[25] Theoretical Study of Natural Product Biosynthesis Using Computational Chemistry.

Hajime Sato*
Chem. Pharm. Bull., accepted.

2023

[24] Mechanistic Investigation of the Degradation Pathways of α-β/α-α Bridged Epipolythiodioxopiperazines (ETPs)

Daiki Kurita, Hajime Sato,* Kazunori Miyamoto, Masanobu Uchiyama*
J. Org. Chem., 2023, 88, 12797–12801.

DOI: 10.1021/acs.joc.3c01061

[23] Unraveling the Role of Prenyl Side-Chain Interactions in Stabilizing the Secondary Carbocation in the Biosynthesis of Variexenol B

Moe Nakano, Rintaro Gemma, Hajime Sato*
Beilstein J. Org. Chem., 2023, 19, 1503-1510.

DOI: 10.3762/bjoc.19.107

invited article

[22] Theoretical Study of the Rearrangement Reaction in Bisorbicillinoid Biosynthesis: Insights into the Molecular Mechanisms Involved

Moe Nakano, Hajime Sato*
Org. Biomol. Chem., 2023, 21, 5366-5371.

DOI: 10.1039/D3OB00728F

[21] Revision of Peniroquesine Biosynthetic Pathway by Retro-biosynthetic Theoretical Analysis: Ring Strain Controls the Unique Carbocation Rearrangement Cascade

Taro Matsuyama,† Ko Togashi,† Moe Nakano, Hajime Sato,* Masanobu Uchiyama*
JACS Au, 2023, 3, 1596-1603.

DOI: 10.1021/jacsau.3c00039

2022

[20] Concertedness and Activation Energy Control by Distal Methyl Group during Ring Contraction/Expansion in Scalarane-type Sesterterpenoid Biosynthesis

Hajime Sato,* Moe Nakano
Chem. Eur. J., 2022, 29, e202203076.

DOI: 10.1002/chem.202203076

[19] Elucidation of Late-stage Biosynthesis of Phomoidride: Proposal of Cyclization Mechanism Affording Characteristic 9-Membered Ring of Fungal Dimeric Anhydride

Shintaro Yamamoto,# Taro Matsuyama,# Taro Ozaki,* Jyunya Takino, Hajime Sato, Masanobu Uchiyama,* Atsushi Minami,* and Hideaki Oikawa
J. Am. Chem. Soc., 2022, 144, 20998-21004. (#: equall contribution)

DOI: 10.1021/jacs.2c09308

[18] DFT Study on the Biosynthesis of Asperterpenol and Preasperterpenoid Sesterterpenoids: Exclusion of Secondary Carbocation Intermediates and Origin of Structural Diversification

Kyoka Sakamoto, Hajime Sato*, Masanobu Uchiyama*
J. Org. Chem., 2022, 87, 6432–6437.

DOI: 10.1021/acs.joc.2c00291

2021

[17] Molecular and Computational Bases for Spirofuranone Formation in Setosusin Biosynthesis

Xingxing Wei, Taro Matsuyama, Hajime Sato,* Dexiu Yan, Pui Man Chan, Kazunori Miyamoto, Masanobu Uchiyama,* and Yudai Matsuda*
J. Am. Chem. Soc., 2021, 143, 17708–17715.

DOI: 10.1021/jacs.1c08336

[16] DFT Study on the Biosynthesis of Verrucosane Diterpenoids and Mangicol Sesterterpenoids: Involvement of Secondary-carbocation-free Reaction Cascades

Hajime Sato,* Bi-Xiao Li, Taisei Takagi, Chao Wang, Kazunori Miyamoto, and Masanobu Uchiyama*
JACS Au, 2021, 1, 1231–1239.

DOI: 10.1021/jacsau.1c00178

Selected as a cover picture.

[15] Theoretical Study on the Mechanism of Spirocyclization in Spiroviolene Biosynthesis

Hajime Sato,* Taisei Takagi, Kazunori Miyamoto, and Masanobu Uchiyama*
Chem. Pharm. Bull., 2021, 69, 1034–1038.

DOI: 10.1248/cpb.c21-00536

Selected as a "Featuerd Article".

2020

[14] DFT Study of a Missing Piece in Brasilane-Type Structure Biosynthesis: An Unusual Skeletal Rearrangement

Hajime Sato,* Takahiro Hashishin, Junichiro Kanazawa, Kazunori Miyamoto and Masanobu Uchiyama*
J. Am. Chem. Soc., 2020, 142, 19830–19834.

DOI: 10.1021/jacs.0c09616

Selected as a cover picture.

[13] Biosynthesis of Indole Diterpene Lolitrems: Radical‐Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton

Yulu Jiang, Taro Ozaki, Mei Harada, Tadachika Miyasaka, Hajime Sato, Kazunori Miyamoto, Junichiro Kanazawa, Chengwei Liu, Jun-ichi Maruyama, Masaatsu Adachi, Atsuo Nakazaki, Toshio Nishikawa, Masanobu Uchiyama, Atsushi Minami,* Hideaki Oikawa*
Angew. Chem. Int. Ed., 2020, 59, 17996–18002.

DOI: 10.1002/anie.202007280

[12] Functional Analysis of a Biosynthetic Gene Cluster Demonstrates Role of Spontaneous Double Bicyclo-ring Formation Including 8π–6π Electrocyclization in Shimalactone Biosynthesis

Isao Fujii,* M. H., K. K., A. U., H. S., K. S., H. T., M. I., S. Y., A. K., R. F., A. H., K. S., T. A., J. I., D. W., Y. G., A. Watanabe, M. Watanabe, Y. Masumoto, J. Kanazawa, Hajime Sato, Masanobu Uchiyama*
Angew. Chem. Int. Ed., 2020, 59, 8464–8470.

DOI: 10.1002/anie.202001024

[11] DFT Study on the Biosynthesis of Preasperterpenoid A: Role of Secondary Carbocations in the Carbocation Cascade

Hajime Sato,* Mami Yamazaki, Masanobu Uchiyama*
Chem. Pharm. Bull., 2020, 68, 487–490.

DOI: 10.1248/cpb.c20-00037

2019

[10] Inherent Atomic Mobility Changes in Carbocation Intermediates During the Sesterterpene Cyclization Cascade

Hajime Sato,* Takaaki Mitsuhashi, Mami Yamazaki, Ikuro Abe, Masanobu Uchiyama*
Beilstein J. Org. Chem., 2019, 15, 1890–1897.

DOI: 10.3762/bjoc.15.184

invited article

[9] 理論計算による生合成経路の探索 生合成リデザインへの挑戦

佐藤玄・王 超・内山 真伸*
ファルマシア (特集：天然物化学研究の新展開）, 2019, 55, 684–688.

DOI: 10.14894/faruawpsj.55.7_684

invited article

[8] Acceleration of Mechanistic Investigations of Plant Secondary Metabolism based on the Computational Chemistry

Hajime Sato, Kazuki Saito, Mami Yamazaki*
Front. Plant Sci., 2019, 10, 802.

DOI: 10.3389/fpls.2019.00802

invited article

2018

[7] Computational Studies on Biosynthetic Carbocation Rearrangements leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Type of Skeleton.

Hajime Sato,* Takaaki Mitsuhashi, Mami Yamazaki, Ikuro Abe,* Masanobu Uchiyama*
Angew. Chem. Int. Ed., 2018, 57, 14752–14757.

DOI: 10.1002/anie.201807139

[6] Structural and Computational Basis for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis.

Yu Nakashima, Takaaki Mitsuhashi, Yudai Mtsuda, Miki Senda, Hajime Sato, Mami Yamazaki, Masanobu Uchiyama,* Toshiya Senda,* Ikuro Abe*
J. Am. Chem. Soc., 2018, 140, 9743–9750.

DOI: 10.1021/jacs.8b06084

[5] The Energetic Viability of ∆1-Piperideine Dimerization in Lysine-derived Alkaloid Biosynthesis.

Hajime Sato, Masanobu Uchiyama, Kazuki Saito, Mami Yamazaki*
Metabolites, 2018, 8, 48–58. invited article

DOI: 10.3390/metabo8030048

[4] Computational Study on a Puzzle in the Biosynthetic Pathway of Anthocyanin: Why an Enzymatic Oxidation/Reduction Process Required for a Simple Tautomerization?

Hajime Sato,* Chao Wang, Mami Yamazaki, Kazuki Saito, Masanobu Uchiyama*
PLoS ONE, 2018, 13, e0198944.

DOI: 10.1371/journal.pone.0198944

[3] Theoretical Study of Sesterfisherol Biosynthesis: Computational Prediction of Key Amino Acid Residue in Terpene Synthase.

Hajime Sato,* Koji Narita, Atsushi Minami, Mami Yamazaki, Chao Wang, Hironori Suemune, Shingo Nagano, Takeo Tomita, Hideaki Oikawa, Masanobu Uchiyama*
Sci. Rep., 2018, 8, 2473.

DOI: 10.1038/s41598-018-20916-x

2017

[2] Focused genome mining of structurally related sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products.

Koji Narita, Hajime Sato, Atsushi Minami, Kosei Kudo, Lei Gao, Chengwei Liu, Taro Ozaki, Motoichiro Kodama, Xiaoguang Lei, Tohru Taniguchi, Kenji Monde, Mami Yamazaki, Chao Wang, Masanobu Uchiyama, Hideaki Oikawa
Org. Lett., 2017, 19, 6696–6699.

DOI: 10.1021/acs.orglett.7b03418

2016

[1] “Cation-Stitching Cascade”: Exquisite Control of Terpene Cyclization in Cyclooctatin Biosynthesis

Hajime Sato, Kazuya Teramoto, Yui Masumoto, Noriyuki Tezuka, Kenta Sakai, Shota Ueda, Yusuke Totsuka, Tetsuro Shinada, Makoto Nishiyama, Chao Wang, Tomohisa Kuzuyama,* Masanobu Uchiyama*
Sci. Rep., 2016, 5, 18471.

DOI: 10.1038/srep18471