研究業績

2021年


[17] Molecular and Computational Bases for Spirofuranone Formation in Setosusin Biosynthesis

Xingxing Wei, Taro Matsuyama, Hajime Sato,* Dexiu Yan, Pui Man Chan, Kazunori Miyamoto, Masanobu Uchiyama,* and Yudai Matsuda*
J. Am. Chem. Soc., 2021, in press.

DOI: 10.1021/jacs.1c08336


JACS

[16] DFT Study on the Biosynthesis of Verrucosane Diterpenoids and Mangicol Sesterterpenoids: Involvement of Secondary-carbocation-free Reaction Cascades

Hajime Sato,* Bi-Xiao Li, Taisei Takagi, Chao Wang, Kazunori Miyamoto, and Masanobu Uchiyama*
JACS Au, 2021, 1, 1231–1239.

DOI: 10.1021/jacsau.1c00178

JACS Au 誌の表紙に採用されました
JACS_AuJACS_cover_Au

[15] Theoretical Study on the Mechanism of Spirocyclization in Spiroviolene Biosynthesis

Hajime Sato,* Taisei Takagi, Kazunori Miyamoto, and Masanobu Uchiyama*
Chem. Pharm. Bull., 2021, 69, 1034–1038.

DOI: 10.1248/cpb.c21-00536

Featured Article に選出されました。
CPB

2020年


[14] DFT Study of a Missing Piece in Brasilane-Type Structure Biosynthesis: An Unusual Skeletal Rearrangement

Hajime Sato,* Takahiro Hashishin, Junichiro Kanazawa, Kazunori Miyamoto and Masanobu Uchiyama*
J. Am. Chem. Soc., 2020, 142, 19830–19834.

DOI: 10.1021/jacs.0c09616

J. Am. Chem. Soc. 誌の表紙に採用されました
JACS TOC JACS

ChemStation スポットライトリサーチ(インタビュー記事)
ChemStation 解説記事

[13] Biosynthesis of Indole Diterpene Lolitrems: Radical‐Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton

Yulu Jiang, Taro Ozaki, Mei Harada, Tadachika Miyasaka, Hajime Sato, Kazunori Miyamoto, Junichiro Kanazawa, Chengwei Liu, Jun-ichi Maruyama, Masaatsu Adachi, Atsuo Nakazaki, Toshio Nishikawa, Masanobu Uchiy
Angew. Chem. Int. Ed., 2020, 59, 17996–18002.

DOI: 10.1002/anie.202007280


[12] Functional Analysis of a Biosynthetic Gene Cluster Demonstrates Role of Spontaneous Double Bicyclo-ring Formation Including 8π–6π Electrocyclization in Shimalactone Biosynthesis

Isao Fujii,* Makoto Hashimoto, Kaori Konishi, Akiko Unezawa, Haruka Sakuraba, Kenta Suzuki, Harue Tsushima, Miho Iwasaki, Satsuki Yoshida, Akane Kudo, Rina Fujita, Aika Hichiwa, Koharu Saito, Takashi Asano, Jun Ishikawa, Daigo Wakana, Yukihiro Goda, Ayumi
Angew. Chem. Int. Ed., 2020, 59, 8464–8470.

DOI: 10.1002/anie.202001024


[11] DFT Study on the Biosynthesis of Preasperterpenoid A: Role of Secondary Carbocations in the Carbocation Cascade

Hajime Sato,* Mami Yamazaki, Masanobu Uchiyama*
Chem. Pharm. Bull., 2020, 68, 487–490.

DOI: 10.1248/cpb.c20-00037


2019年


[10] Inherent Atomic Mobility Changes in Carbocation Intermediates During the Sesterterpene Cyclization Cascade

Hajime Sato,* Takaaki Mitsuhashi, Mami Yamazaki, Ikuro Abe, Masanobu Uchiyama*
Beilstein J. Org. Chem., 2019, 15, 1890–1897.

DOI: 10.3762/bjoc.15.184

invited article

[9] 理論計算による生合成経路の探索 生合成リデザインへの挑戦

佐藤玄・王 超・内山 真伸*
ファルマシア (特集:天然物化学研究の新展開), 2019, 55, 684–688.

DOI: 10.14894/faruawpsj.55.7_684

invited article

[8] Acceleration of Mechanistic Investigations of Plant Secondary Metabolism based on the Computational Chemistry

Hajime Sato, Kazuki Saito, Mami Yamazaki*
Front. Plant Sci., 2019, 10, 802.

DOI: 10.3389/fpls.2019.00802

invited article

2018年


[7] Computational Studies on Biosynthetic Carbocation Rearrangements leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Type of Skeleton.

Hajime Sato,* Takaaki Mitsuhashi, Mami Yamazaki, Ikuro Abe,* Masanobu Uchiyama*
Angew. Chem. Int. Ed., 2018, 57, 14752–14757.

DOI: 10.1002/anie.201807139


[6] Structural and Computational Basis for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis.

Yu Nakashima, Takaaki Mitsuhashi, Yudai Mtsuda, Miki Senda, Hajime Sato, Mami Yamazaki, Masanobu Uchiyama,* Toshiya Senda,* Ikuro Abe*
J. Am. Chem. Soc., 2018, 140, 9743–9750.

DOI: 10.1021/jacs.8b06084


[5] The Energetic Viability of ∆1-Piperideine Dimerization in Lysine-derived Alkaloid Biosynthesis.

Hajime Sato, Masanobu Uchiyama, Kazuki Saito, Mami Yamazaki*
Metabolites, 2018, 8, 48–58. invited article

DOI: 10.1371/journal.pone.0198944


[4] Computational Study on a Puzzle in the Biosynthetic Pathway of Anthocyanin: Why an Enzymatic Oxidation/Reduction Process Required for a Simple Tautomerization?

Hajime Sato,* Chao Wang, Mami Yamazaki, Kazuki Saito, Masanobu Uchiyama*
PLoS ONE, 2018, 13, e0198944.

DOI: 10.1371/journal.pone.0198944


[3] Theoretical Study of Sesterfisherol Biosynthesis: Computational Prediction of Key Amino Acid Residue in Terpene Synthase.

Hajime Sato,* Koji Narita, Atsushi Minami, Mami Yamazaki, Chao Wang, Hironori Suemune, Shingo Nagano, Takeo Tomita, Hideaki Oikawa, Masanobu Uchiyama*
Sci. Rep., 2018, 8, 2473.

DOI: 10.1038/s41598-018-20916-x


2017年


[2] Focused genome mining of structurally related sesterterpenes: Enzymatic Formation of Enantiomeric and Diastereomeric Products.

Koji Narita, Hajime Sato, Atsushi Minami, Kosei Kudo, Lei Gao, Chengwei Liu, Taro Ozaki, Motoichiro Kodama, Xiaoguang Lei, Tohru Taniguchi, Kenji Monde, Mami Yamazaki, Chao Wang, Masanobu Uchiyama, Hideaki
Org. Lett., 2017, 19, 6696–6699.

DOI: 10.1021/acs.orglett.7b03418


2016年


[1] “Cation-Stitching Cascade”: Exquisite Control of Terpene Cyclization in Cyclooctatin Biosynthesis

Hajime Sato, Kazuya Teramoto, Yui Masumoto, Noriyuki Tezuka, Kenta Sakai, Shota Ueda, Yusuke Totsuka, Tetsuro Shinada, Makoto Nishiyama, Chao Wang, Tomohisa Kuzuyama,* Masanobu Uchiyama*
Sci. Rep., 2016, 5, 18471.

DOI: 10.1038/srep18471


山梨大学