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1Enzymatic skeletal editing reaction forming the 1,3,5-triazine core during biosynthesis of the anticancer nucleoside analog 5-azacytidine

A. Umezawa†, T. Tsunoda†, Y. Nakashima†, Y.-L. Wang, T. Yoneda, C. Maruyama, N.-S. Hsu, T. Matsuyama, K. Miyamoto, H. Sato, A. Shimose, R. Takazawa, Y. Hamano, T.-L. Li, Y. Inokuma, M. Uchiyama, Y. Ogasawara*, H. Morita*, T. Dairi*

Nature Catalysis, 2026, accepted.

DOI: 10.1038/s41929-026-01611-x

2Formal Chemoenzymatic Skeletal Editing of Fusicoccane Core to Access 6-Aza-fusicoccanes

Seiya Endo, Eigo Fukuda, Ken-ya Hori, Kei-ichi Murai, Atsushi Nakayama, Yoko Yasuno, Masayoshi Arai, Hajime Sato, Tomohisa Kuzuyama, Tetsuro Shinada

JACS Au 2026, in press.

DOI: 10.1021/jacsau.6c00833

3<a id="2024JACS_Au">DFT Study on Retigerane-type Sesterterpenoid Biosynthesis: Initial Conformation of GFPP Regulates Biosynthetic Pathway, Ring-construction Order and Stereochemistry</a>

Yuichiro Watanabe, Takahiro Hashishin, Hajime Sato,* Taro Matsuyama, Masaya Nakajima, Jun-ichi Haruta, Masanobu Uchiyama*

JACS Au, 2024, 4, 3484–3491.

DOI: 10.1021/jacsau.4c00313

4Revision of Peniroquesine Biosynthetic Pathway by Retro-biosynthetic Theoretical Analysis: Ring Strain Controls the Unique Carbocation Rearrangement Cascade

Taro Matsuyama,† Ko Togashi,† Moe Nakano, Hajime Sato,* Masanobu Uchiyama*

JACS Au, 2023, 3, 1596-1603.

DOI: 10.1021/jacsau.3c00039

5Elucidation of Late-stage Biosynthesis of Phomoidride: Proposal of Cyclization Mechanism Affording Characteristic 9-Membered Ring of Fungal Dimeric Anhydride

Shintaro Yamamoto,# Taro Matsuyama,# Taro Ozaki,* Jyunya Takino, Hajime Sato, Masanobu Uchiyama,* Atsushi Minami,* and Hideaki Oikawa

J. Am. Chem. Soc., 2022, 144, 20998-21004. (#: equall contribution)

DOI: 10.1021/jacs.2c09308

6Molecular and Computational Bases for Spirofuranone Formation in Setosusin Biosynthesis

Xingxing Wei, Taro Matsuyama, Hajime Sato,* Dexiu Yan, Pui Man Chan, Kazunori Miyamoto, Masanobu Uchiyama,* and Yudai Matsuda*

J. Am. Chem. Soc., 2021, 143, 17708–17715.

DOI: 10.1021/jacs.1c08336

7DFT Study on the Biosynthesis of Verrucosane Diterpenoids and Mangicol Sesterterpenoids: Involvement of Secondary-carbocation-free Reaction Cascades

Hajime Sato,* Bi-Xiao Li, Taisei Takagi, Chao Wang, Kazunori Miyamoto, and Masanobu Uchiyama*

JACS Au, 2021, 1, 1231–1239.

DOI: 10.1021/jacsau.1c00178

8DFT Study of a Missing Piece in Brasilane-Type Structure Biosynthesis: An Unusual Skeletal Rearrangement

Hajime Sato,* Takahiro Hashishin, Junichiro Kanazawa, Kazunori Miyamoto and Masanobu Uchiyama*

J. Am. Chem. Soc., 2020, 142, 19830–19834.

DOI: 10.1021/jacs.0c09616

9Biosynthesis of Indole Diterpene Lolitrems: Radical‐Induced Cyclization of an Epoxyalcohol Affording a Characteristic Lolitremane Skeleton

Yulu Jiang, Taro Ozaki, Mei Harada, Tadachika Miyasaka, Hajime Sato, Kazunori Miyamoto, Junichiro Kanazawa, Chengwei Liu, Jun-ichi Maruyama, Masaatsu Adachi, Atsuo Nakazaki, Toshio Nishikawa, Masanobu Uchiyama, Atsushi Minami,* Hideaki Oikawa*

Angew. Chem. Int. Ed., 2020, 59, 17996–18002.

DOI: 10.1002/anie.202007280

10Functional Analysis of a Biosynthetic Gene Cluster Demonstrates Role of Spontaneous Double Bicyclo-ring Formation Including 8π–6π Electrocyclization in Shimalactone Biosynthesis

Isao Fujii,* M. H., K. K., A. U., H. S., K. S., H. T., M. I., S. Y., A. K., R. F., A. H., K. S., T. A., J. I., D. W., Y. G., A. Watanabe, M. Watanabe, Y. Masumoto, J. Kanazawa, Hajime Sato, Masanobu Uchiyama*

Angew. Chem. Int. Ed., 2020, 59, 8464–8470.

DOI: 10.1002/anie.202001024

11Computational Studies on Biosynthetic Carbocation Rearrangements leading to Quiannulatene: Initial Conformation Regulates Biosynthetic Route, Stereochemistry, and Type of Skeleton.

Hajime Sato,* Takaaki Mitsuhashi, Mami Yamazaki, Ikuro Abe,* Masanobu Uchiyama*

Angew. Chem. Int. Ed., 2018, 57, 14752–14757.

DOI: 10.1002/anie.201807139

12Structural and Computational Basis for Dramatic Skeletal Rearrangement in Anditomin Biosynthesis.

Yu Nakashima, Takaaki Mitsuhashi, Yudai Mtsuda, Miki Senda, Hajime Sato, Mami Yamazaki, Masanobu Uchiyama,* Toshiya Senda,* Ikuro Abe*

J. Am. Chem. Soc., 2018, 140, 9743–9750.

DOI: 10.1021/jacs.8b06084